Hi Justme,
From reading your post, it looks like the CyBorD is your wife's first treatment. I believe that Daratumumab typically is reserved for relapsed patients. Will your wife have a stem cell transplant? I'm in Scotland, where Dara is available in combination with other drugs either for first line (followed by SCT) or as second line treatment (i.e. after relapse), or on its own as fourth line. For any treatment regime there always seems to be conditions attached, and that can impact on whether we can access that treatment. Can you discuss it with the consultant?
After my own relapse two years ago, the intention was to put me on Daratumumab. I had previously received CyBorD, then VTD (Velcade, Thalidomide, Dex), and Thalidomide/Dex maintainance, which put me in remission for over three years. I actually started treatment a few days ago, but not Daratumumab (it's a long story but over the last nine months I have had many new investigations and now been diagnosed with a rare type of B-Cell Lymphoma as the cause my AL Amyloidosis).
Best wishes, and good luck with your quest.