Author Topic: Response criteria  (Read 357 times)

Justme

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  • Reason for joining: Husband of Amyloid patient
  • Diagnosed: March 2021
Response criteria
« on: November 26, 2021, 07:02:51 am »
Hello. Can anyone please direct me to the response to treatment criteria for AL Amyloidosis that is used when dFLC response can’t be used? Think it should be using paraprotein levels.

Miriam Vered

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Re: Response criteria
« Reply #1 on: November 26, 2021, 01:44:52 pm »

About 10-15% of patients with AL amyloidosis have only minimally abnormal FLC, so FLC cannot be used for accurate monitoring.  A measurable M-protein (also known as paraprotein), defined as >5g/l, is useful for monitoring the haematological response to chemotherapy in these patients.


1-2% of patients with AL amyloidosis lack a measurable serum or urine marker to monitor response at present.  Ongoing studies are evaluating a new method called high sensitivity flow cytometry that may have a role.

Justme

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  • Posts: 5
  • Reason for joining: Husband of Amyloid patient
  • Diagnosed: March 2021
Re: Response criteria
« Reply #2 on: November 26, 2021, 03:07:05 pm »
Thank you for your quick response Miriam. I think I knew this much - what I am hoping to discover is the definition of complete/very good/partial responses using the M protein only - where dFLC is not possible.

Miriam Vered

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Re: Response criteria
« Reply #3 on: December 13, 2021, 09:20:33 am »
This is Professor Gillmore's answer to your question:


Complete – disappearance of M protein
VGPR – M protein only detectable on immunofixation, not detectable on immunoelectrophoresis
PR – M protein dropped to <5 if starting value was >10